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Body weight decreased by about 10 kg in the first 3 months and then gradually increased again with the change in diet in the last 3 months (+7.3 kg) (Table 5)

The GLP-1 and GIP receptor pathways have been maximally stimulated, and the system has recalibrated around that stimulation

Medications that can enhance the activity of insulin (so-called incretin mimetics) can help to overcome insulin resistance caused by SGAs (and potentially by other psychotropic medications) and essentially lead to weight loss through enhanced fuel efficiency. Metformin, typically dosed up to 1,000 mg twice daily with meals, has increasingly become recognized as a first-line strategy to attenuate weight gain and glycemic dysregulation from SGAs via its ability to reduce insulin resistance

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