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If your levothyroxine dose has been stable for years, you may see little change

Elevated GIP levels and duodenal K cell hyperplasia (62) have also been reported in HFD-treated mice, while Gipr deficiency protects mice from HFD-, leptin deficiency- or ovariectomy-induced weight gain (63, 64)

Many patients start noticing changes within the first few weeks, but significant weight loss usually becomes apparent after 2-3 months of consistent use

Missed doses are inevitable over a multi-month protocol