risks with semaglutide Liraglutide vs Semaglutide: Comparing Weight Loss & Other Benefits Semaglutide side effects for diabetes

Lancet Diabetes Endocrinol 9(9):595605 Matthews DR, Paldanius PM, Proot P et al (2019) Glycaemic durability of an early combination therapy with vildagliptin and metformin versus sequential metformin monotherapy in newly diagnosed type 2 diabetes (VERIFY): a 5-year, multicentre, randomised, double-blind trial

Ozempic shortages Semaglutide has been in short supply for about two years, largely because it has been increasingly prescribed off-label to people who don't have diabetes

Gum disease progression may accelerate in some patients, possibly due to changes in immune function, blood flow, or the oral bacterial environment

Blood in stool is not listed as a recognised adverse reaction in the MHRA/EMC Summary of Product Characteristics (SmPC) for Ozempic, nor does it appear in the extensive safety data from pivotal clinical trials such as the SUSTAIN programme

It should not be used in patients with a personal or family history of medullary thyroid carcinoma