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Description
GLP-1 receptor activation leads to increased cAMP, which inhibits the signaling pathways downstream of these ADP receptors, thereby reducing platelet activation [92]
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A large retrospective study found that patients who used phentermine continuously for more than 12 months maintained greater weight loss at 24 months (7.4% more than the referent group) without increased cardiovascular risk

doi: 10.1136/gutjnl-2015-310572 73 LinnebjergHKotharePAParkSMaceKReddySMitchellMet al

Diabetes, pregnancy and breast-feeding | Treatment summaries | BNF NICE