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The psychological cost also matters

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Together, these changes create a profound shift in your baseline hunger set point

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Research shows that a significant proportion of weight lost on GLP-1 medications can come from lean mass, with estimates suggesting up to 3040% of total weight loss may be muscle and bone density, rather than fat (Neeland et al

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For employers and insurers, the "initial question" was whether to cover GLP-1s for obesity, said Virta CEO Sami Inkinen

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