glp-1 agonist tablets Popular obesity drug fails in hotly anticipated Alzheimer's trials | Science Wegovy pill: Oral GLP-1 receptor

doi: 10.1111/jnc.13731 72 NassarNNAl-ShorbagyMYArabHHAbdallahDM

[57] While the transplacental transfer of GLP-1 appears limited, potential indirect impacts on fetal growth and development cannot be excluded

Clinical trials showed modest results, and AOD-9604 was not pursued through full FDA drug approval

Concomitantly, autophagy was reported to also reduce the hepatocyte apoptosis caused by steatosis and endoplasmic reticulum stress, possibly through the GLP-1RA-stimulated GLP-1R-mediated activation of the EB transcription factor of the autophagy-lysosome pathway, thus reducing the accumulation of liver lipids (201)

Chin Med J (Engl) (2017) 130(3):36571