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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Cherney DZI, et al

By stimulating GLP-1 receptors, semaglutide promotes feelings of fullness and satisfaction, leading to reduced calorie intake

this remains investigational, not a clinical application

Your genetic predisposition to respond to GLP-1 signaling also plays a critical rolesome individuals are naturally stronger responders due to variations in the GLP1R gene

EClinicalMedicine DOI:10.1016/j.eclinm.2026.104007 Abstract The effectiveness of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on binge eating in patients with obesity: a systematic review and meta-analysis Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs), widely used for weight management and type 2 diabetes, may reduce binge eating behaviours and body dissatisfaction, but there are concerns that they might increase eating restraint