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16 The patterns indicating improvement in headache and visual results, albeit not statistically significant, imply intricate underlying pathophysiological pathways that need additional exploration in prospective therapeutic trials

These medications work by mimicking endogenous GLP-1 with enhanced resistance to degradation by DPP-4

It activates GLP-1 receptors located in the pancreas, brain, and digestive system

The new label includes references to some of those postmarketing risks, including intestinal obstruction, [and] severe constipation including fecal impaction. Some patients who took Zepbound have filed lawsuits, accusing Eli Lilly of failing to properly warn them that Zepbound could increase their risk of severe gut problems, including bowel obstructions, pancreatitis, and gastroparesis

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