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GLP-1s for Chronic Kidney Disease GLP-1s for Advanced Liver Disease In August 2025, the FDA approved Wegovy (semaglutide) to treat adults with a type of liver disease called metabolic-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), when used alongside diet and exercise

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The Research Behind It A landmark 2021 trial published in the New England Journal of Medicine (Wilding et al.) found that once-weekly semaglutide 2.4 mg produced an average body weight reduction of 14.9% over 68 weeks in adults with obesity, compared to 2.4% in the placebo group

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