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It's a naturally occurring hormone, we synthesize it pharmacologically, give it back at very high doses, and it amplifies the satiety or appetite signals so they feel less hungry

The safety profile aligned with previous SURMOUNT trials, with gastrointestinal effects reported as the primary adverse events for both medications

GLP-1 and Strength Training: Avoiding a Common Pitfall Losing weight on a GLP-1 medication

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Summary While the ability of sulfonylureas to improve glycemic control is robust, the risk of hypoglycemia and weight gain reduce the desirability of this drug class