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Studies show patients lose an average of 10-15% of their body weight over one year

Specific dose figures from those trials appear in the cited PMIDs (PMID 40544433, PMID 37364590) for research reference

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Pinch the skin gently between your thumb and forefinger to create a fold, which ensures the needle reaches subcutaneous tissue rather than going too shallow (intradermal) or too deep (intramuscular)

The idea of using a metric such as the clinically meaningful change can be applied to assess whether the outcome is not only statistically relevant, but would be meaningful to a person with a particular disease