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Increased cytoplasmic Ca +2 triggers mitochondrial ATP generation and insulin exocytosis from insulin granules

A similar approach was applied to the design of peptide 20s C terminus that occupies the hydrophobic binding groove of ECD, with residues (A19 P , F22 P , V23 P , W25 P , L26 P and L27 P ) adopted from GIP, GLP-1 and GCG (Figs

As such, the study of this complex endocrine organ, might help us to create new pharmacological tools to amend the specific molecular axis that drive T2DM and the associated co-morbidities known to affect the cardiovascular (25, 26) and renal system (27, 28)
