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Similarly, the LEAN trial showed that liraglutide was associated with remarkably higher rates of NASH resolution and a reduction in fibrosis progression relative to placebo

ASC: apoptotic speck containing protein

3 GLUCAGON-LIKE PEPTIDE-1 Despite being identified later than GIP, GLP-1 quickly became the focus of intensive research, such that fewer than 20 years were to elapse between the description of its incretin effect and the approval of the first highly successful GLP-1 RA drug class for treatment of T2D

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