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We report a significant reduction in total cholesterol in individuals with type 1 diabetes treated with a GLP-1 RA

Furthermore, in smaller studies of patients with recent acute and advanced HF, irrespective of T2D status (62, 63), treatment with liraglutide was associated with a nonsignificant increase in CV mortality and hHF (30%, P = 0.17) (62)

In agreement with the role of CYP8B1 in the regulation of BA composition, we found that the percentage of TMCA, the most abundant non-12-OH BA (MCA), was increased significantly in the gallbladder bile of MMI + T3-5d mice compared to MMI mice (Fig

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