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The Diabetes Prevention Programme, a large RCT comparing Metformin, ILI and placebo, indicated that after 21 years of follow-up, there was no significant reduction in cancer incidence comparing ILI to placebo (RR 0.96, 95% CI = 0.791.18) [14]

[DOI] [PubMed] [Google Scholar] 16.Zhao L., Cheng Z., Lu Y., et al

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There is also a serious risk of euglycaemic diabetic ketoacidosis in people taking SGLT2 inhibitors (e.g., dapagliflozin, empagliflozin) who fast or follow low-carbohydrate diets

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