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Notably, 48% of participants planned to take GLP-1RA indefinitely

Approximately 76% of the trial population were White, 14% Asian, and 4% Black or African American

Given the observed increased risk of colorectal cancer among patients receiving GLP-1 receptor agonists, clinicians should approach long-term prescribing of these agents with careful consideration, particularly in individuals with additional risk factors for colorectal cancer, such as a family history, obesity, inflammatory bowel disease, or long-standing type 2 diabetes

More serious but rare complications include pancreatitis and, in animal studies, thyroid C-cell tumours, though the clinical relevance to humans remains under investigation

At 3 months, patients achieved an average weight loss of 5.9%, and at 6 months, the weight loss increased to 10.9%