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The clinical trial data from SURMOUNT-1 enrolled participants with a mean BMI of 38, and the results showed dramatic weight loss outcomes across dosing tiers

However, researchers also stated that weight loss results with exenatide were similar to the results you might experience from following a low calorie diet

Diabetes Obes Metab 9:869878 Ahren B, Foley JE, Ferrannini E et al (2010) Changes in prandial glucagon levels after a 2-year treatment with vildagliptin or glimepiride in patients with type 2 diabetes inadequately controlled with metformin monotherapy

These GLP-1 analogues were found effective for T2DM because they prolong the incretin effect in patients [27]

[17] Yet, at the same time, GLP-1s appeared to protect against late-stage retinopathy when compared with insulin