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Make sure to switch between the upper arm and abdomen to lower irritation

While the systemic biological effects of semaglutide that indirectly benefit MASLD/MASH are robustly validated, a knowledge gap persists concerning the drug's direct effects on the liver, alongside the scientific controversy surrounding the gene and protein expression of GLP1 receptor (GLP1R) in the liver [12]

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Some providers recommend tapering doses rather than immediate cessation to allow metabolic adjustment, though evidence on optimal discontinuation protocols remains limited

Considering these developments, Semaglutide has a substantial opportunity to become a blockbuster drug, because more than 50% of the worlds population will be living with either overweight or obesity by 2035 as per World Obesity Federation