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In a rat model of cavernosal dysfunction, Dalaklioglu et al

The rationale is that two smaller doses produce a more even medication level throughout the week, avoiding the peak-and-trough pattern that creates intense digestive effects early in the week and diminishing effects late in the week
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Additionally, rapid dose escalation amplifies risk compared to gradual titration schedules

Meals above 500 calories may be too large for a suppressed appetite
