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Understanding why weight regain happens after discontinuing GLP-1 treatment could be crucial for determining their long-term health impacts and the best way to prescribe them in the future

Furthermore, early safety trials that included kidney outcomes as secondary endpoints hinted at potential renal benefits associated with these medication classes

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HMB activates the mammalian target of rapamycin (mTOR) signaling pathway, which promotes muscle protein synthesis, while concurrently inhibiting proteolytic processes through the ubiquitin-proteasome pathway

12 As to whether GLP-1 drugs were associated with changes in DME, there is still not yet enough conclusive evidence