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Itchy skin can develop during tirzepatide treatment, though it is not among the most commonly reported side effects

As of early 2026, several potent single, dual, and triple incretin receptor agonists are in Phase 2/3 trials for MASH including : Survodutide : A dual glucagon (GCGR)/GLP-1 receptor agonist that has shown significant MASH resolution in Phase 2 trials

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Eli Lillys triple agonist demonstrated an average weight loss of 16.8% in a Phase 3 trial for the treatment of type 2 diabetes.

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