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Keywords: GLP-1 receptor agonist, substance use disorder, craving, reward circuitry, gutbrain axis, mesolimbic pathway, dopamine, synaptic plasticity, vagal signaling, neuroinflammation, semaglutide, addiction 1

Note: Tirzepatide is often grouped with GLP-1 medications, but it is technically a dual GIP/GLP-1 receptor agonist not a pure GLP-1 drug

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16 Therefore, adjustment of background mealtime insulin is important to prevent hypoglycemia when starting a GLP-1 RA
