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Broadly, GLP-1RAs act to increase insulin secretion, decrease glucagon secretion, delay gastric emptying, and induce satiety [14, 19]

Emerging evidence suggests that GLP-1 receptors are not confined to pancreatic islets but are also expressed in cardiomyocytes and vascular endothelial cells (50, 51)

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Rodgers, Buel D., and Christopher W

Extensive research over the past decade, including large-scale trials and real-world studies, has examined this question thoroughly