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Because a 4.5 mg dose uses about half the reconstituted vial, plan vial supply accordingly

GLP-1RAs modify gastric emptying and can influence bile acidrelated signaling and downstream intestinal transport processes [114]

The STEP trials reported nausea in approximately 44% of participants on semaglutide 2.4 mg versus 17.4% on placebo

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According to FDA prescribing information, these include: Nausea (occurring in 1544% of patients depending on formulation and dose) Vomiting (524% of patients) Diarrhea (830% of patients) Abdominal pain (511% of patients) Constipation (324% of patients) These gastrointestinal symptoms typically emerge during dose escalation and often diminish over time as physiological tolerance develops