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Clinical Evidence: Retatrutide's Impressive Results In a recent phase 2 trial for obesity, retatrutide demonstrated remarkable efficacy: Up to 24.2% weight loss at 48 weeks with the highest dose, surpassing the weight loss seen with both semaglutide(15-17%)and tirzepatide (22.5%) at their respective highest doses

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Oral anti-hyperglycemic medications, other than sulfonylureas and SGLT2 inhibitors, provide a reasonable alternative to insulin and can be continued safely perioperatively depending upon the type of surgery and the patient is expected to resume oral intake soon postoperatively.