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Rheumatol (Oxford)

It showed the world that a GLP-1 receptor agonist could produce meaningful, sustained weight loss in people without diabetes

The brawl at hand is over GLP-1 drugs like Ozempic and Mounjaro that were developed for diabetes but have found massive reach for weight loss

For colorectal cancer, reductions in circulating insulin and systemic inflammation are plausible mechanisms, although further tissue-level validation is needed (Figure 5)

The magnitude of the benefits of GLP-1RA and SGLT-2 inhibitors on MACE are similar, ranging from 12 to 14% reduction of risk, but only GLP-1RA may reduce the risk of stroke