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13 An increase in the use of GLP1 RA as initial treatment in drugnaive patients has been observed in Denmark 14 regardless that no randomized clinical trial evidence has been published on how or whether GLP1 RA outperforms metformin in these patients

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doi: 10.1016/s0735-6757(97)90200-x

Although most cardiovascular outcome trials (CVOTs) of GLP-1 RA have shown significant reductions in 3-point major adverse cardiovascular events (MACE), findings on hospitalization for HFa key secondary endpointexhibit heterogeneity across studies