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Administration of GLP-1 and exendin-4 promoted neurite outgrowth in cultured dorsal root ganglion (DRG) neurons, presumably explaining the increased nerve fibers observed in biopsies of IBS individuals [51]

JAMA, 331(14), 12301232

Specifically, semaglutide is approved for individuals with a body mass index (BMI) of 30 or higher (classified as obese) or a BMI of 27 with at least one weight-related health condition such as high blood pressure, type 2 diabetes, or high cholesterol

Metabolic and Body Assessments: Employ tools to understand your body composition and metabolism
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2019 Sep;128:94105
