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The primary concerns include gastrointestinal side effects (nausea, diarrhoea, abdominal pain) that may be difficult to distinguish from UC flares, increased dehydration risk, and the challenge of monitoring disease activity whilst on treatment

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Shedding typically begins 24 months after starting or increasing a GLP-1 and can last several months

As GLP-1 and GLP-2 have become important targets in the treatment of type 2 diabetes, obesity and malabsorptive conditions 16,17,62 , we therefore characterized gut microbiome signatures in DIO mice treated with liraglutide, a selective GLP-1 receptor agonist, or GUB09-145, a potent dual GLP-1/GLP-2 agonist 26