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Stephanie Young Moss, PharmD Medical Reviewer Stephanie Young Moss, PharmD, has worked in pharmacy, community outreach, regulatory compliance, managed care, and health economics and outcomes research

These medicines mimic the action of the naturally occurring GLP-1 hormone, which is released by the intestine in response to food intake

However, as they are not FDA approved and have not been vetted in long-term trials there is no way to guarantee their safety, efficacy or potency. Now, as drug manufacturers successfully push the FDA to remove semaglutide and tirzepatide from the shortage list, access to compounded versions may soon disappear

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Thus, more targeted, well-designed clinical trials are required for providing clearer evidence on the efficacy, optimal dose, and safety profiles of these drugs in AD and PD