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Wang T, Hong JL, Gower EW, et al

Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: Role of GLP-1 isoforms in Glut4 receptor trafficking

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For weight loss specifically, Phase 2 trial data suggests retatrutide produces greater average weight loss (22-24%) compared to tirzepatide (18-22%) at maximum doses

We assessed the GLP-1R agonists (exenatide, liraglutide, dulaglutide, semaglutide) and the dual GIPR/GLP-1R co-agonist tirzepatide as separate classes