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[8,16] Once activated, Akt regulates several crucial downstream mechanisms, including glucose uptake through GLUT3/GLUT4 transporters, stabilization of neuronal membrane potential through Na + /K + -ATPase activity, modulation of GABAergic neurotransmission, and regulation of mitochondrial function through mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) pathways

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The GLP-1R is expressed in various tissues, including but not limited to pancreatic -cells, various cell types of the gastrointestinal tract, neurons throughout the peripheral and central nervous system (CNS), the kidney, the vasculature, and the heart [8,9,10]

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