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Recently, we reported that hyperleptinemia is indeed a driving force for diet-induced obesity, as the isolated intervention involving just an increase in circulating leptin levels, either by a transgenic approach using an adipocyte-specific leptin transgene or by frequent administration of exogenous leptin, are sufficient to promote weight gain in diet-induced obese mice (1416)

Additionally, it enhances autophagy, regulates gut microbiota, and boosts the effectiveness of other anti-tumor drugs

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J Clin Invest (2013) 123(6):27306

GLP-1 is produced by l-cells primarily in the distal parts of the intestine, but it can also activate a Gs-coupled GLP-1 receptor (GLP-1R) resulting in proliferation of human coronary artery endothelial cells as well as -cells in pancreas (Egholm et al., 2016)