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Direct head-to-head comparison of tirzepatide vs semaglutide was conducted in the SURPASS-2 trial, which showed tirzepatide 15mg weekly produced significantly greater HbA1c reduction (-2.46% vs -1.86%) and weight loss (-12.4 kg vs -6.2 kg) compared to semaglutide 1mg weekly in type 2 diabetes

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Some patients maintain weight loss indefinitely on their current dose while others need intervention

Glucagon-like peptide-1 receptor agonists (e.g., semaglutide and liraglutide) (GLP-1 RA) were first approved by the Food and Drug Administration (FDA) in 2005 for the treatment of Type 2 Diabetes but have only recently revolutionized the market as a weight loss drug for the non-diabetic patient

GLP-1, FGF-19 and FGF-21 were elevated after bariatric surgery, but not significantly different between PBH and non-PBH patients