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Repeatedly skipping doses may also cause gastrointestinal side effects when restarting treatment

In conclusion, both SGLT2-i and GLP1-RA seem to have several effects on RAAS, though additional studies are needed to clarify this relationship

Two reasons working simultaneously
2019;33(10) doi: 10.1002/jbt.22388

However, much remains to be seen in terms of optimization of the triple-agonists, which includes strategically customizing ideal receptor activity ratios and limiting adverse events
