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At lower price points, the cost-benefit analysis that led to coverage removal may flip back toward coverage, especially as long-term outcomes data showing reduced cardiovascular events and diabetes progression continues to accumulate

However, it has not achieved the same level of success as stand-alone GLP-1 receptor agonists like semaglutide and dulaglutide

arginine and proline, cysteine and methionine metabolism pathways [44]

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However, the trial was neither powered nor designed to detect differences in MACE, and the follow-up duration was insufficient to draw long-term conclusions