pharmacokinetics of glp-1 receptor agonists a long-acting agonist in minipigs Emerging Trends in the Development

GLP-1 medications interact with certain drugs, supplements, and substances that may reduce efficacy or increase side effects

This Comment highlights emerging evidence and advocates for clinical strategies that prioritize muscle preservation to ensure the long-term success and safety of pharmacological weight management.

Limitations The major limitations of the studies that are included in this systematic review are the enrollment of healthy subjects and insufficient data in conditions that might affect pharmacokinetics (e.g., kidney dysfunction)

GLP-1 Agonists: Transforming Diabetes & Weight Management From glucose control to significant weight loss, GLP-1 receptor agonists are redefining how we approach metabolic diseases

It highlights the PIONEER clinical trial programme results, and reviews the efficacy, safety and tolerability.