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A recent in vivo study in healthy subjects showed that acute intravenous infusion of GLP-1 during a pancreatic clamp, in which insulin and glucagon levels were maintained at basal levels, caused a reduction in hepatic glucose production, suggesting a potential direct effect on gluconeogenesis [11]

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This finding is particularly significant, as CAP is known to bind to the transmembrane domains of TRPV1 channels 60 , suggesting that exendin 939 is a selective and potent antagonist for pain relief without competitively displacing CAP at its binding site

Gardenia is an evergreen flowering plant which belong to the Rubiaceae family, endemic to regions of Southeast Asia
