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Exendin-4 is a high potency agonist and truncated exendin-(939)-amide an antagonist at the glucagon-like peptide 1-(736)-amide receptor of insulin-secreting beta-cells
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These results taken together suggest that adding even mild amounts of GR agonism (to increase energy expenditure) on top of a dual agonist like Tirzepatide is able to produce even more pronounced decreases in weight
It may be prudent to allow your body to adjust to Wegovy for several weeks before introducing probiotic supplements
