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Multicenter Study of Perioperative Ischemia Research Group

This underscores the need for both RWE and RCTs in parallel and reinforces the need to need to run clinical trials that reflect real-world populations, a topic explored in more detail in our blog Obesity trials on trial Some health improvement seen with GLP-1 therapy may be a direct effect of weight loss, rather than unique drug effect as seen by improvements in liver and kidney health 4

13 While GLP-1 agonist-induced weight loss can decrease mechanical load through the musculoskeletal system and improve aspects of physical function, the resulting negative effects on tendons, impaired muscle function, and joint degradation can persist after a healthy weight has been achieved

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This clarity transforms hesitation into determination, giving each client the power to take control of their health