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GLP-1 RAs are unique due to their A1C-lowering potential with effects on both fasting and postprandial blood glucose values

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Tirzepatide is only available as pre-filled pens (Mounjaro or Zepbound) for patient use, and any reconstitution of powder formulations must be performed by qualified healthcare professionals in controlled aseptic facilities

Ethical and feasibility concerns also limit the design of such trialsfor instance, it may not be justifiable to randomize patients to specific agents solely to assess safety outcomes, especially when some newer agents offer established cardiovascular and renal benefits