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A critical consideration is that diabetes itself substantially increases gastroparesis riskaffecting up to 5% of patients with type 1 diabetes and 1% with type 2 diabetes

Data extraction, risk of bias assessment, and meta-analysis were performed using standardized methods with a random-effects model

These neurobiological findings indicate central engagement of mesolimbic circuits relevant to addiction and support a potential role for GLP-1R agonists in modulating incentive salience and dopaminergic tone, even in the absence of overt clinical behavioral differences [79]

doi: 10.1210/en.2010-0956