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GLP-1 receptor agonists increase the risk of gallstone formation and related biliary complications, with liraglutide showing approximately 1.6-2.1 times high...

At the same time, payer policies often require discontinuation of GLP-1 therapy when a patients BMI drops below a set threshold, inadvertently triggering a frustrating cycle of weight loss and regainthe so-called yo-yo effect. This not only impacts ongoing adherence and persistence but also undermines the long-term cost-effectiveness of these therapies for healthcare systems

- What is best practice when someone reaches their goal weight or decides to stop treatment

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