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The term had circulated in patient communities and across TikTok for years, but it reached a mass audience in 2024, when Oprah Winfrey devoted a primetime special, "Shame, Blame and the Weight Loss Revolution," to weight-loss medications and spoke candidly about how they quieted her own food noise

But the last laugh always goes to the jester, even if hes laughing to himself in the algorithmic insane asylum

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Applying Occams razor to these results Data from the SELECT trial clearly demonstrated that semaglutide could reduce risk of MACE among patients with overweight or obesity, but the fact that participants on this drug also lost more weight raised a critical question as to whether we could truly interpret these results as evidence of an independent effect on CV health