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Both medications affect appetite and digestion, and both interact with the metabolic changes of menopause

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It is essential for patients to remain well-hydrated, aiming for at least 2 liters of water daily, as dehydration can exacerbate feelings of fatigue

Digestive symptoms present a particular diagnostic challenge

DXA body composition data from retatrutide's Phase 2 sub-study, published in The Lancet Diabetes & Endocrinology (June 2025), confirmed that lean mass loss occurs alongside fat loss, consistent with patterns seen across the GLP-1 drug class