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Description
FLOW is the first dedicated kidney outcomes trial with a GLP-1RA that includes people with T2D at high or very high risk for CKD progression and is specifically designed to provide evidence on the effects of semaglutide on kidney outcomes

Gut hormones as pharmaceuticals

Kuwata H, Yabe D, Murotani K, Fujiwara Y, Haraguchi T, Kubota S, et al

This effect may be partly due to weight loss, though other mechanisms may also contribute to cardiovascular benefits demonstrated in large-scale studies

These findings were presented at the CHEST Annual Meeting 2025