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For researchers starting a comparative protocol, the practical implication is that tirzepatide offers a broader reference base for benchmarking assay performance and expected magnitudes of effect, while retatrutide provides a more mechanistically novel reference for triple-agonist work
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But retatrutide, the triple agonist that hits GLP-1, GIP, and glucagon receptors simultaneously, introduced something the bodybuilding community had never seen before

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Overall, SGLT2 inhibitors seem to have a more pronounced effect on VAT and EAT compared to SAT leading to a reduction of inflammation and oxidative stress, which is associated with better metabolic outcomes