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In the current review, we discussed the dysregulation of IGF-1/GLP-1 signaling in neurodegenerative manifestations of ALS like a genetic anomaly, oligodendrocyte degradation, demyelination, glial overactivation, immune deregulation, and neuroexcitation

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Preliminary study shows GLP-1 receptor agonists alter alcohol response, suggesting potential for reducing cravings and intoxication in obese individuals.