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What happens to my usual diabetes treatment
Importantly, despite their wide-spread usage, patient responses to GLP-1 M are heterogeneous
The most recent understanding of this deficit suggests that it relates to deterioration of the GLP-1 effect, with impaired capacity to secrete insulin, increasing insulin resistance, and hyperglycemia, perhaps leading to a decrease in GLP-1 receptor expression and resulting in GLP-1 resistance (7)
Meyer-Rsenberg B, Pavlidis M, Stupp T, Thanos S
Phase 2 data of retatrutide, a similar triple agonist developed by Eli Lilly, has shown a remarkable 24% weight loss after 48 wk of treatment, without reaching a plateau (1)
