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The GLP-1 receptor agonist exendin-4 is one of the agents used in the treatment of type 2 diabetes [146] and is a long-acting receptor agonist of GLP-1 that also produces weight loss [147-149]

The anorectic and thermogenic effects of estradiol can be direct, through genomic and non-genomic mechanisms, or indirect, through activation of peripheral mediators such as cholecystokinin (CCK), insulin, leptin and GLP-1

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Conclusively, GLP-1RAs have great research potential in the field of AD treatment